李毅,男,1961年10月出生,理学博士,现为北京大学生命科学学院生物技术系副主任、教授、博士生导师。
研究领域:(1)Focusing on the interactions bewteen rice dwarf virusmovement protein (MP) and cytoskeleton proteins (including actin andmicrotube proteins) and plasmodesmata in the aspects of molecular biology and cell biology; Functional mapping of RDV MP and studying the MP mutantson the effects on virus cell-to-cell movement and mediated resistance against virus infections in transgenic plants; Cloning the host factor(s)involving in virus cell-to-cell movement and virus replication.
(2)研究调节病毒复制的细胞调节因子。
(3)植物基因工程
科研课题:(1).转基因植物外源和内源基因共抑制(cosuppression)问题的研究,国家自然科学基金项目,1997.1-1999.12.
(2).TMV外壳蛋白突变体对病毒粒子组装和突变体外壳蛋白介导抗性的研究,国家科委863项目,1996.1 - 2000.12.
(3).花卉花色基因工程育种,北大-云南合作项目,1998-2000.
(4).花卉花期基因调控研究,深圳市科技局资助项目,1996-2000.
(5).水稻矮缩病毒(RDV)细胞间运动蛋白的作用机理研究,国家自然科学基金项目,1998.1-2000.12,.
(6).玉米矮缩病毒基因的克隆和转化,科技部转基因专项计划,1999-2001。
(7).Molecular Biology and cell biology of rice dwarf virus movementprotein, Rockefeller Foundation grant. 1999-2001.
代表性论文:迄今,已在国内外专业学术刊物上发表论文60多篇,出版专著一本。近期发表文章:
Xu, H., Li, Y. (1998): The rice dwarf phytoreovirus segment S11 encodes a nucleic acid-binding protein. Virology, 240: 267-272.Mao, Z., Li, Y. (1998): The 42K protein of rice dwarf phytoreovirus is a postcleavage product of the 46K outer capsid protein encoded by genome segment S8. Archives of Virology 143:1831-1838.
Zhang, F., Li, Y. (1997): Molecular cloning and functional analysis of major core protein gene (S3) of rice dwarf virus Chinese isolate. Acta Virologica 41: 161-168.
Zheng, H., Li, Y. (1997): Recovery of transgenic rice plants expressing rice dwarf virus outer coat protein gene (S8).
Theoretical and Applied Genetics 94: 522-527.
Li, Y., Wei, C.H. (1996): Immunodetection of beet necrotic yellow vein virus RNA3 encoded protein in different host plants and tissues. Acta Virologica 40: 67-72.